ischemic stroke — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7946	AER-271		Aquaporin
	AER-271 is an inhibitor of aquaporin-4.		Aquaporin
T39341	FCPR03		PDE
	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...		PDE
T23146	PHA 568487 free base	PHA 568487	AChR
	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia...		AChR
T3074	CHIR 98024	CHIR98014	GSK-3 , S6 Kinase
	CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.		GSK-3 , S6 Kinase
T0368	Cinepazide maleate	MD-67350,Vasodistal,Brendil	Calcium Channel
	Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator.		Calcium Channel
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK
T26645	Aptiganel	CNS 1102,CNS-1102,CNS1102	NMDAR
	Aptiganel (CNS-1102) is a non-competitive NMDA antagonist, a peptide that may be used to study acute ischemic stroke.		NMDAR
T77442	Glenzocimab	ACT017	Others
	Glenzocimab (ACT017) is a Fab fragment of a humanized anti-GPVI monoclonal antibody. Glenzocimab demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model. Glenzocimab has been studied ...		Others
T39463	Asundexian	BAY 2433334,Asundexian,BAY2433334,BAY-2433334	Factor Xa
	Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa, thereby inhibiting its activity.Asundexian has an IC50 of 1 n...		Factor Xa
T7355	IC87201		Others , iGluR
	IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.		Others , iGluR
T3871	Daucosterol	Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A	Glucosidase
	Daucosterol (Sitogluside) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol(β-Sitosterol β-D-glucoside) has efficient and inexpensive neuroprotectant effect, to contribute to IGF1...		Glucosidase
T90611	PF-03049423
	PF-03049423 is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of approximately 0.2 nM for rat and human thrombomodulin. PF-03049423 can be used in studies about acute ischemic stroke studies.
T3527	TRC051384	TRC 051384	HSP
	TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ...		HSP
T21757	BRL 52537 hydrochloride		Opioid Receptor
	BRL 52537 hydrochloride is a selective and specific KOR agonist which has been implicated in neuroprotection from ischemic neuronal injury[1]. It is used for research into potential treatments for stroke and heart attack...		Opioid Receptor
T78141	LFHP-1c		Phospholipase
	LFHP-1c, a neuroprotective PGAM5 inhibitor, demonstrates efficacy in preserving blood-brain barrier integrity following ischemic stroke. It achieves this by binding to endothelial PGAM5, thereby inhibiting its phosphatas...		Phospholipase
T13112	Tat-NR2B9c	Tat-NR2Bct,NA-1	NO Synthase , iGluR
	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...		NO Synthase , iGluR
T31206	Darexaban	YM 150,Darexaban, Tanexaban,YM150	Factor Xa
	Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...		Factor Xa
T70540	Pinokalant	LOE-908	SARS-CoV , TRP/TRPV Channel
	Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem...		SARS-CoV , TRP/TRPV Channel
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase
T34086	Platonin	NK 19
	Platonin is a therapeutic immunomodulating medicine and a possible medicine against ischemic stroke.